{"id":"57f9983c-116c-4486-bc42-39cc9beea8b9","title":"青藏高原150例藏族人群全基因组芯片数据（2019-2021）","title_en":"Whole genome microarray data of 150 Tibetan populations in the Qinghai Tibet Plateau (2019-2021)","serial":"","user_limit":"为尊重知识产权、保障数据作者的权益、扩展数据中心的服务、评估数据的应用潜力，请数据使用者在使用数据所产生的研究成果中（包括公开发表的论文、论著、数据产品和未公开发表的研究报告、数据产品等成果），明确注明数据来源和数据作者。对于转载（二次或多次发布）的数据，作者还须注明原始数据来源。","instructions":"以文本格式储存，文件名称为xxxx.vcf.gz，xxxx表示样本在本实验室的编号。\n数据读取方式：可以先解压缩，然后用文本程序（如Editplus）打开。","description":"青藏高原是对人类生存最具挑战性的环境之一，被誉为地球的“第三极”。平均海拔在4000米以上，4000m的氧分压仅为海平面60％左右。高原缺氧对于人类生存是一个强烈的选择压力，大部分高原非适应性个体暴露于高原缺氧环境会导致红细胞数量增加（红细胞增多症）和红细胞积压（Hematocrit, HCT）水平升高。高原藏族遗传背景单一，长期高海拔环境对高原适应相关基因有正选择作用，造成不同海拔梯度在相关的单核苷酸多态性（SNP）存在稳定连锁遗传差异，适于研究高海拔适应性表型与基因型间的关联。本研究采用DNA微阵列（DNA Array）的方法，对比了150例高原藏族及非藏族东亚人的男性全基因组芯片数据，每个样品获取约70万位点（包括核基因组、线粒体DNA和Y染色体）分型结果，分析其差异SNPs、基因及信号通路，并检测高原藏族男性为适应高海拔低氧环境产生的分子水平的适应性进化特征。该数据有助于从核基因组角度解析藏族人群的遗传适应性，通过与高原周边人群数据的比较，可以较为全面地了解高原土著男性的适应性进化。为研究人类及生物进化、探究高低海拔人群的分子水平差异性、不同地理环境人群的同源关系和低氧对于基因的选择作用等提供基础的遗传参考数据。","doi":"10.11888/Others.tpdc.271881","projection":"","language":"zh","share_type":"protected","east":94.05,"west":84.03,"south":28.56,"north":32.26,"scale":null,"crs":null,"filesize":1607.68,"share_policy":"c","ts_created":"2021-11-28T14:19:14.649897+08:00","doi_type":"拥有自主知识产权","ts_updated":"2021-12-14T14:20:49.125902+08:00","time_description":"","datas_group":0,"time_description_en":"","data_format":null,"project":[11],"specials":[],"cite":null,"review_status":5,"review_invite":[{"user_name":"于黎 ","username":"于黎","email":"yuli@ynu.edu.cn","is_cancel_expert":false}],"review_editor":{"id":42421,"last_login":"2022-04-08T15:16:51.670544+08:00","username":"任慧霞","email":"510727846@qq.com","is_active":true,"is_staff":true,"user_name":"任慧霞"},"data_sources":null,"temporal_resolution":"Yearly","spatial_resolution":"1km - 10km","license":"Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","fund":[6],"subtopics":{"metadata":"57f9983c-116c-4486-bc42-39cc9beea8b9","three_pole":null,"third_pole":"XDA20040102"},"username":"XDA20040102","review_time":null,"protected_duration":24,"protected_describe":null,"is_important":false,"hit_count":369}